Table 3.
Univariable and multivariable Cox regression analyses for overall survival of melanoma patients and CAF parameters by cell counts
| Variable (LO/HI) | Control OS | Anti-PD-1 OS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable analysis | Univariable analysis | Multivariablea analysis per variable | Multivariablea analysis with Thy1, SMA, FAP | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Thy1+/total | 1.65 (0.87–2.88) | 0.12 | 4.66 (2.34–8.82) | < 0.0001 | 4.67 (2.19–9.53) | 0.0001 | 3.02 (1.44–6.10) | 0.0044 |
| SMA+/Thy1+ | 0.45 (0.22–1.07) | 0.070 | 0.34 (0.18–0.68) | 0.0029 | 0.32 (0.16–0.67) | 0.0027 | 0.62 (0.30–1.31) | 0.20 |
| FAP+/Thy1+ | 0.57 (0.37–0.88) | 0.012 | 4.11 (2.05–9.14) | < 0.0001 | 4.64 (2.27–10.52) | < 0.0001 | 3.61 (1.65–8.56) | 0.0011 |
Abbreviations: CAF cancer-associated fibroblast, CI confidence interval, HI high, HR hazard ratio, LO low, OS overall survival
aCox proportional hazards model included age, sex, mutation status, stage, treatment, and prior immune checkpoint blockade as covariates