Table 5.

DFS and BCSS according to Kyn, Trp and the Kyn/Trp ratio

Outcome	Parameter	Kyn			Trp			Kyn/Trp ratio
		Low	High	p value	Low	High	p value	Low	High	p value
DFS	N patients	100	96	NA	95	101	NA	98	98	NA
	N events	14	14	NA	11	17	NA	13	15	NA
	5-year-DFS	80%	79%	0.994	81%	78%	0.602	85%	73%	0.523
	HR (95% CI)	1.003 (0.477–2.106)			1.224 (0.572–2.616)			1.273 (0.605–2.679)
BCSS	N patients	94	94	NA	90	98	NA	93	95	NA
	N events	6	2	NA	5	3	NA	5	3	NA
	5-year-BCSS	92%	98%	0.167	94%	96%	0.288	94%	97%	0.586
	HR (95% CI)	0.341 (0.069–1.691)			0.469 (0.112–1.964)			0.673 (0.161–2.822)

Kyn kynurenine, Trp tryptophan, DFS disease-free survival, N number, HR hazard ratio, BCSS breast cancer-specific survival