Table 3.
Stress related genes within the ten investigated eukaryotes. Numbers reflect the number of putative genes retrieved within each gene category (See Additional file 1 for details)
| Gene class/category | Tardigrada | Arthropoda | Nematoda | Chordata | Ascomycota | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Es | Rc | Rv | He | Dm | Ce | Hs | Xt | Dr | Sc | |
| Tardigrade unique proteinsa | 0 | 23 | 32 | 25 | 0 | 0 | 0 | 0 | 0 | 0 |
| Late Embryogenesis Abundant (LEA) b | 5 | 6 | 9 | 7 | 0 | 2 | 0 | 0 | 0 | 0 |
| Heat shock proteinsc | 56 | 65 | 59 | 117 | 79 | 65 | 90 | 77 | 96 | 45 |
| RNA/DNA Chaperones_Cold Shock Domain containingd | 3 | 1 | 1 | 1 | 1 | 6 | 5 | 5 | 3 | 0 |
| DNA repair | (58) | (91) | (74) | (80) | (61) | (57) | (77) | (73) | (74) | (57) |
| TP53 e | 0 | 1 | 1 | 1 | 1 | 1 | 3 | 3 | 3 | 0 |
| Base excision repairf | 18 | 31 | 24 | 27 | 15 | 13 | 22 | 21 | 19 | 14 |
| Mismatch repairg | 15 | 20 | 13 | 16 | 10 | 12 | 14 | 14 | 14 | 14 |
| Nucleotide excision repairh | 18 | 23 | 18 | 21 | 15 | 16 | 18 | 17 | 19 | 15 |
| Non-homologous end-joiningi | 0 | 5 | 6 | 6 | 8 | 3 | 5 | 5 | 5 | 5 |
| Homologous recombinationj | 7 | 11 | 12 | 9 | 12 | 12 | 15 | 13 | 14 | 9 |
| Antioxidative stress | (70) | (79) | (79) | (89) | (82) | (89) | (66) | (53) | (68) | (29) |
| Superoxide dismutases (SOD_CuZn; SOD_Mn) | 8 | 14 | 17 | 15 | 6 | 6 | 4 | 2 | 5 | 3 |
| Catalase (CAT) | 0 | 4 | 4 | 4 | 2 | 3 | 1 | 2 | 1 | 2 |
| Peroxiredoxins (PRDX) | 5 | 7 | 9 | 12 | 9 | 3 | 6 | 6 | 6 | 3 |
| Thioredoxins (TXN; TXNRD; TXNL; TMX) | 12 | 13 | 10 | 12 | 14 | 11 | 14 | 12 | 14 | 8 |
| Glutaredoxin (GLRX) | 5 | 4 | 3 | 3 | 4 | 6 | 4 | 4 | 4 | 5 |
| Glutathione-disulfide reductase (GSR) | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| Glutathione peroxidase (GPX) | 2 | 1 | 1 | 1 | 2 | 8 | 8 | 6 | 9 | 3 |
| Glutathione synthetase (GSS) | 1 | 2 | 2 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| Soluble glutathione S-transferases (GST soluble) | 35 | 30 | 31 | 34 | 38 | 49 | 22 | 13 | 20 | 2 |
| Microsomal glutathione S-transferases (microsomal GST) | 0 | 2 | 0 | 2 | 3 | 0 | 4 | 5 | 6 | 0 |
| Glucose-6-phosphate dehydrogenase (G6PD) | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| Peroxisomal biogenesis factorsk | 4 | 3 | 5 | 2 | 17 | 13 | 21 | 21 | 23 | 12 |
| Trehalose metabolism | (3) | (9) | (10) | (9) | (5) | (8) | (2) | (2) | (2) | (7) |
| Trehalose-phosphate synthase/phosphatase (TPS-TPP) | 0 | 1 | 1 | 0 | 2 | 3 | 0 | 0 | 0 | 4 |
| Trehalases (PGGHG/ATHL1, TREH) | 3 | 8 | 9 | 9 | 3 | 5 | 2 | 2 | 2 | 3 |
Es: Echiniscoides cf. sigismundi, Rc: Richtersius cf. coronifer, Rv: Ramazzottius cf. varieornatus, He: Hypsibius exemplaris, Dm: Drosophila melanogaster, Ce: Caenorhabditis elegans, Hs: Homo sapiens, Xt: Xenopus tropicalis, Dr: Danio rerio, Sc: Saccharomyces cerevisiae
a= CAHS; SAHS; MAHS; RvLEAM; Dsup
b= LEA; DUR-1
c= HSP90; HSP70; HSP60; HSP40; HSP20; HSP10
d= CSP; lin28; Y-box
e= Tp53; p63/p73
f= UNG; XRCC1; XRCC3; XRCC2; PNKP; Tdp1; APTX; POLB; POLD; POLE; FEN1; PCNA; PARP1–4
g= MSH2; MSH6; MSH3; MSH4; MSH5; MLH1; PMS2; MLH3; Exo1; RFC
h= XPC; CETN2; Rad23; DDB; GTF2H1/TFIIH1; GTF2H2/TFIIH2; GTF2H3/TFIIH3; GTF2H4/TFIIH4; CDK7; ERCC3; ERCC2; ERCC1; XPA; ERCC5
i= XRCC6; XRCC5; CLP/XRCC4; LIG4; NHEJ1
j= MRE11; Rad50; NBS1; Rad51; CtIP; BRCA1; BRCA2; Slx1; SLX4; Mus81; EME1
k= PEX1; PEX2; PEX3; PEX5; PEX6; PEX7; PEX10; PEX11; PEX12; PEX13; PEX14; PEX16; PEX19; PEX26; PXMP2; PMP34; PXMP4; TYSND1