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. 2019 Jul 17;10:904. doi: 10.3389/fphys.2019.00904

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Copyright © 2019 Zafarnia, Mrugalla, Rix, Doleschel, Gremse, Wolf, Buyel, Albrecht, Bode, Kiessling and Lederle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mathematical model describing liver regeneration. A mathematical model has been developed describing liver regeneration at organ and tissue scale. (A) The scheme shows the interrelations between liver cell compartments (hepatocytes, Kupffer cells, recruited macrophages, and endothelial cells) during liver regeneration. (B) The simulated cell compartment curves show the normalization of relative cell amounts after PHx. (C) The simulated measurement curves were computed based on the simulated cell compartment curves. After iterative adjustment the simulated curves describing liver volume, total macrophages, Kupffer cells, and angiogenesis showed similar time courses as the experimental data. (D) Diagram showing the time courses for liver volume, CD68⁺ macrophage density, CD169⁺ macrophages, and angiogenic activity of the experimental data acquired in mice after PHx.