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. 2019 Jul 17;10:1586. doi: 10.3389/fimmu.2019.01586

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Copyright © 2019 Brisse and Ly.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Organization and known structures of RIG-I and MDA5. (A,B) Graphic representing the domain organization of RIG-I (A) and MDA5 (B). (C–E) Known structures of human RIG-I and MDA5, with X-ray crystallography structures of RIG-I Hel-CTD (C) and MDA5-Hel-CTD (D) interacting with dsRNA, and CARD1/2 of RIG-I interacting with the MAVS CARD domain (E). In (C–E), the helicase domains are shown in red, the CTD in purple, RNA in green, the CARD1 domain in blue, the CARD2 domain in aquamarine and the MAVS CARD domain in orange (C) was adapted from reference (61), (D) from reference (62), and (E) from reference (63).