Table 2.

The histopathological findings of the liver in the Se/GSH (+) and (−) rats treated with flutamide.

Dose Level of Flutamide (mg/kg/day)	Se/GSH (+)		Se/GSH (−)
	0	150	0	150
Hypertrophy, hepatocyte, centrilobular	−: 5	±: 3	−: 5	±: 2
		+: 2		+: 3
Infiltration, inflammatory cell, periportal	−: 5	−: 5	−: 5	−: 4
				±: 1
Single cell necrosis, hepatocyte, centrilobular	−: 5	−: 5	−: 5	−: 4
				±: 1
Necrosis, hepatocyte, focal, subcapsular	−: 5	−: 5	−: 5	−: 5
				+: 1

−: Finding absent, ±: very slight, +: slight. Se/GSH (+): normal rats, Se/GSH (−): Se/GSH-depleted rats.