Table 4:

Pulse Oximetry Performance Characteristics in All Comers, Patients without Significant Liver Disease and HPS with Severe Hypoxemia

A: Performance Characteristics in All Comers

B: Performance Characteristics in Patients without Lung Disease

C: Performance Characteristics in HPS with PaO2 < 60 mm Hg and All Comers

SpO2 Cutoff	Sensitivity (95% CI)	Specificity (95% CI)	NPV (95% CI)	PPV (95% CI)
< 96%	0.28 (0.18 – 0.38)	0.84 (0.80 – 0.89)	0.82 (0.77 – 0.86)	0.32 (0.21 – 0.43)
≤ 94%	0.21 (0.12 – 0.31)	0.93 (0.90 – 0.96)	0.82 (0.78 – 0.86)	0.44 (0.28 – 0.61)
≤ 97% (Optimal)	0.56 (0.45 – 0.67)	0.57 (0.51 – 0.63)	0.83 (0.78 – 0.88)	0.25 (0.19 – 0.32)

Cohort	Sensitivity (95% CI)	Specificity (95% CI)	NPV (95% CI)	PPV (95% CI)
< 96%	0.28 (0.18 – 0.38)	0.91 (0.86 – 0.96)	0.68 (0.61 – 0.75)	0.66 (0.49 – 0.82)
≤ 94%	0.21 (0.12 – 0.31)	0.96 (0.93 – 0.99)	0.67 (0.61 – 0.74)	0.76 (0.58 – 0.94)
≤ 97% (Optimal)	0.56 (0.45 – 0.67)	0.68 (0.60 – 0.76)	0.72 (0.64 – 0.80)	0.51 (0.40 – 0.61)

Cohort	Sensitivity (95% CI)	Specificity (95% CI)	NPV (95% CI)	PPV (95% CI)
< 96%	0.71 (0.38 – 1.00)	0.83 (0.79 – 0.87)	0.99 (0.98 – 1.00)	0.08 (0.01 – 0.14)
≤ 94%	0.71 (0.38 – 1.00)	0.91 (0.88 – 0.94)	0.99 (0.98 – 1.00)	0.14 (0.03 – 0.25)
≤ 88% (Optimal)	0.71 (0.38 – 1.00)	0.99 (0.98 – 1.00)	0.99 (0.99 – 1.00)	0.62 (0.29 – 0.96)