Table 4:
Association of Oral Anticoagulation Prescription to Stroke by Burden of Device-Detected AF
| Unadjusted* | Multivariable Regression*,† | Propensity-Adjusted with IPTW*,‡ | ||||||
|---|---|---|---|---|---|---|---|---|
| Device-detected AF Burden | HR§ (95% CI) | P value | HR§ (95% CI) | P value | HR§ (95% CI) | P value | ||
| AF > 6 minutes | 0.63 (0.27–1.45) | 0.27 | 0.62 (0.26–1.43) | 0.29 | 0.67 (0.45–0.99) | 0.04 | ||
| AF > 1 hour | 0.77 (0.35–1.71) | 0.52 | 0.79 (0.35–1.77) | 0.57 | 0.88 (0.57–1.36) | 0.56 | ||
| AF > 6 hours | 0.57 (0.24–1.33) | 0.19 | 0.52 (0.22–1.25) | 0.14 | 0.59 (0.37–0.95) | 0.03 | ||
| AF > 24 hours | 0.34 (0.12–0.95) | 0.04 | 0.28 (0.10–0.81) | 0.02 | 0.27 (0.14–0.54) | 0.0002 | ||
Cox proportional hazards models with shared frailty (to adjust for site) and competing risk of death;
Multivariable model includes all baseline variables with univariate associations with P < 0.10 (cardiac implantable electronic device type, age, clinical AF, hypertension, heart failure, myocardial infarction, diabetes, CHADS2 score, niacin/fibrates prescription, statin prescription);
Propensity score model fit assessed by Hosmer-Lemeshow goodness-of-fit and C statistic (p = 0.61, C statistic = 0.62). Covariate standardized mean differences reported in Supplemental Table 3;
Risk of stroke when anticoagulation is prescribed within 90 days of device-detected index AF episode.
AF: atrial fibrillation; CI: confidence interval; HR: hazard ratio; IPTW: inverse probability of treatment weights