Table 1. Conserved genes and pathways that mitigate proliferation suppression following formaldehyde exposure.
Human and S. cerevisiae gene names, along with the yeast systemic names are provided. ‘Sensitivity’ indicates the level of sensitivity to formaldehyde noted in our previously published yeast screen (20), whereas ‘Description’ provides brief annotations of the human gene to specific DDR or DNA metabolic pathways (69,70)
| Human Gene | S. cerevisiae Gene | Systematic Name | Sensitivity | Description |
|---|---|---|---|---|
| CACNA1G | CCH1 | YGR217W | Not Sensitive | Calcium Voltage Channel |
| DMC1 | ECM30 | YLR436C | Sensitive | HR/DSB Repair/Mitosis |
| ERCC6 | RAD26 | YJR035W | Not Sensitive | NER/BER |
| FANCB | - | - | - | Fanconi Anemia Pathway |
| FANCE | - | - | - | Fanconi Anemia Pathway |
| FEN1 | RAD27 | YKL113C | Moderately | BER/DNA Replication |
| MPLKIP | CDC5P | YMR001C | Essential | Cell Cycle/ Mitosis |
| MSH2 | MSH2 | YOL090W | Moderately | Mismatch Repair |
| MSH5 | MSH5 | YDL154W | Not Sensitive | Mismatch Repair |
| NUDT1 | NPY1 | YGL067W | Not Sensitive | BER |
| PMS2P4 | PMS1 | YNL082W | Not Sensitive | Mismatch Repair |
| PRKDC | - | - | - | NHEJ/DSB Repair |
| RAD17 | RAD24 | YER173W | Sensitive | Cell Cycle/DNA Damage Checkpoint |
| RAD52 | RAD52 | YML032C | Sensitive | HR/DSB Repair/DNA Replication |
| RBBP8 | SAE2 | YGL175C | Not Sensitive | Cell Cycle/DNA Damage Checkpoint |
| RBM14 | PSP2 | YML017W | Sensitive | Mitochondrial mRNA Splicing |
| RECQL | SGS1 | YMR190C | Sensitive | HR/DSB Repair/Replication |
| RPS19BP1 | - | - | - | Ribosomal Subunit |
| RRM2B | RNR4 | YGR180C | Sensitive | DNA Damage Checkpoint/Replication |
| SIRT6 | SIR2 | YDL042C | Moderately | Chromatin Modification/DNA Replication |
| TREX2 | - | - | - | HR/DSB Repair |
| UIMC1 | - | - | - | HR/DSB Repair/Chromatin Modification |
| XRCC3 | RAD57 | YDR004W | Not Sensitive | HR/DSB Repair |