. Author manuscript; available in PMC: 2019 Jul 24.

Published in final edited form as: J Am Acad Dermatol. 2018 Jan 10;78(3):560–578. doi: 10.1016/j.jaad.2017.10.007

Table VII.

Recommendations for clinical information and pathology report for suspected cSCC

Clinical information provided to pathologist

Strongly recommended

• Age

• Sex

• Anatomic location

• Recurrent lesion

Recommended

• Size of lesion

• Immunosuppression

• History (especially radiation, burn, organ transplant)

Elements to be included in final pathology report (excision specimens)

Strongly recommended

• Degree of differentiation^*

• Presence of aggressive histologic subtype^†

• Depth of invasion, mm

• Clark level of invasion

• Perineural invasion

• Lymphovascular invasion

• Invasion of fascia, muscle, or bone

• Number of high-risk features^‡

• Margin status

• TNM stage (AJCC)

Recommended

• Inflammation

• Infiltrative strands, single cells, small nests

• Diameter of largest involved nerve

AJCC, American Joint Committee on Cancer; cSCC, cutaneous squamous cell carcinoma; TNM, tumor, node, metastasis.

Well differentiated, moderately differentiated, poorly differentiated, or undifferentiated.

^†

Acantholytic, adenosquamous, or carcinosarcomatous subtypes.

^‡

High-risk features include thickness greater than 2 mm, Clark level IV or V, poorly differentiated/undifferentiated, site on mucosa lip or ear, perineural invasion, and lymphovascular invasion.