Table 5.

Univariate and multivariate analysis of the predictors of DFS in the overall study population.

	Univariate cox regression		Multivariate cox regression
	Hazard ratio	P	Hazard ratio	P
Non-functioning tumors	13.68 (3.34–56.11)	<0.001
G3	13.29 (7.93–22.16)	<0.001	4.51 (2.32–8.78)	<0.001
T3/4	10.86 (6.70–17.59)	<0.001
N1 status	8.50 (5.07–14.26)	<0.001	2.46 (1.25–4.83)	0.009
M1 status	10.97 (5.81–20.71)	<0.001
LVI	8.43 (5.14–13.83)	<0.001	3.62 (1.57–8.34)	0.003
PNI	7.07 (4.17–11.99)	<0.001	2.61 (1.36–5.01)	0.004
Resection margin	3.50 (1.73–7.05)	<0.001	4.20 (1.58–11.12)	0.004

Values in parentheses are 95% CI.

LVI, lymphovascular invasion; PNI, perineural invasion.