Table 2.

Results from sex-specific quantile regression analyses: associations of circulating chemerin and adiponectin concentrations with liver enzymes and MRI-quantified liver fat content (LFC).

		Men (n = 1926)				Fasting men (n = 1129)
		Chemerin per 29 ng/mL		Adiponectin per 5 μg/mL		Chemerin per 29 ng/mL		Adiponectin per 5 μg/mL
		Beta (SthErr)	P	Beta (SthErr)	P	Beta (SthErr)	P	Beta (SthErr)	P
ALT	lin	0.042 (0.012)	<0.01	−0.058 (0.020)	<0.01	0.012 (0.008)	0.17	−0.009 (0.008)	0.24
	spl	−0.007 (0.002)	<0.01	0.016 (0.006)	<0.01	–
AST	lin	−0.005 (0.005)	0.28	0.011 (0.005)	0.02	−0.002 (0.006)	0.79	−0.025 (0.018)	0.16
	spl	–		–		–		0.017 (0.006)	<0.01
AP	lin	0.025 (0.007)	<0.01	0.012 (0.012)	0.31	0.018 (0.010)	0.07	0.007 (0.017)	0.69
GGT	lin	0.054 (0.016)	<0.01	0.009 (0.011)	0.40	0.016 (0.013)	0.21	0.009 (0.013)	0.47
	spl	−0.008 (0.002)	<0.01	–		–		–
LFCa	Lin	0.585 (0.216)	<0.01	−0.825 (0.171)	<0.01	0.672 (0.258)	<0.01	−0.827 (0.207)	<0.01
		Women (n = 2025)				Fasting women (n = 1309)
		Chemerin per 29 ng/mL		Adiponectin per 5 μg/mL		Chemerin per 29 ng/mL		Adiponectin per 5 μg/mL
		Beta (StdErr)	P	Beta (StdErr)	P	Beta (StdErr)	P	Beta (StdErr)	P
ALT	lin	0.004 (0.004)	0.24	−0.003 (0.003)	0.26	0.009 (0.005)	0.07	−0.003 (0.004)	0.38
AST	lin	0.005 (0.003)	0.05	0.006 (0.002)	0.01	0.005 (0.004)	0.14	0.010 (0.003)	<0.01
AP	lin	0.038 (0.010)	<0.01	0.016 (0.008)	0.06	0.042 (0.012)	<0.01	0.011 (0.011)	0.28
GGT	lin	0.010 (0.005)	0.04	−0.007 (0.003)	0.04	0.009 (0.006)	0.15	−0.005 (0.004)	0.25
LFCa	lin	−0.554 (0.190)	<0.01	−0.516 (0.068)	<0.01	−0.879 (0.264)	<0.01	−0.324 (0.080)	<0.01
	spl	0.149 (0.045)	<0.01	–		0.198 (0.058)	<0.01	–

Quantile regression was used to predict the median. The estimated coefficients (beta), standard errors (StdErr) and P values are given. Quantile regression models were adjusted for age, waist circumference, glycated hemoglobin, systolic blood pressure, total triglycerides and high-sensitivity C-reactive protein. A spline term (spl) was added to the linear term (lin) of the respective adipokine when the usage of splines represented a gain in model quality as assessed by a likelihood ratio test.

^aMagnetic resonance imaging (MRI) examinations were performed in a subsample of 840 men (577 of them fasting) and 895 women (686 of them fasting).

ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; GGT, gamma-glutamyl-transferase.