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. 2019 Jun 28;23(8):5588–5599. doi: 10.1111/jcmm.14457

Figure 4.

Figure 4

Bryostatin‐1 treated Il‐10 −/− mice show less apoptotic intestinal epithelial cells than the untreated Il‐10 −/− mice. (A and B) Bry‐1‐treated Il‐10 −/− mice exhibited fewer TUNEL‐positive cells per crypt than untreated Il‐10 −/− mice, and the number of TUNEL‐positive cells in the Bry‐1‐treated mice was similar to that in WT mice. (C and D) The protein level of the antiapoptotic factor Bcl‐2 was increased in Bry‐1‐treated Il‐10 −/− mice compared with untreated Il‐10 −/− mice; however, the level in the Bry‐1‐treated mice was still lower than that in WT mice. In contrast, compared to the untreated Il‐10 −/− mice, the Bry‐1‐treated Il‐10 −/− mice showed a significant decrease in Bax and cleaved caspase‐3 expression, but the expression in the Bry‐1‐treated mice was still higher than that in the WT mice. Bry‐1, Bryostatin‐1; WT, wild‐type; and NS, no significance. At least three independent experiments with six to eight mice in each group were performed, with one representative experiment is shown. The data are expressed as the mean ± SD. ▼ P < 0.05