Figure 5.

Antiapoptotic effect of Bryostatin‐1 on Il‐10 ^−/− mice may be partly mediated by activating Nrf2 signalling. (A and B) The levels of both Nrf2 and its downstream factor HO‐1 were significantly decreased in Bry‐1‐treated Il‐10 ^−/− mice compared to untreated Il‐10 ^−/− mice, and the levels in the Bry‐1‐treated mice were similar to those in WT mice. These results were confirmed by PCR (C). Bry‐1, Bryostatin‐1; WT, wild‐type; and NS, no significance. At least three independent experiments with six to eight mice in each group were performed, with one representative experiment is shown. The data are expressed as the mean ± SD. ^▼ P < 0.05