Table 3.

Change From Baseline to Week 12: Hemodynamic Parameters

	ASD			VSD			PDA
	Baseline	12 Weeks	P	Baseline	12 Weeks	P	Baseline	12 Weeks	P
HR, beats/min	88.00 ± 11.88	81.00 ± 6.26	0.021	77.54 ± 9.22a	75.50 ± 9.59	0.238	82.25 ± 13.06	80.06 ± 13.16	0.279
mRAP,b mm Hg	7.85 ± 3.08	6.33 ± 3.57	0.177	8.04 ± 4.40	7.49 ± 5.97	0.607	10.38 ± 9.48	7.69 ± 6.16	0.279
mPAP, mm Hg	65.58 ± 11.12	60.85 ± 8.96	0.054	86.32 ± 19.93c	76.58 ± 16.81	<0.001	91.71 ± 17.34c	86.04 ± 16.83	0.245
Qpi, L·min−1·m−2	2.8 ± 1.0	4.1 ± 1.8	0.008	2.8 ± 1.0	3.4 ± 1.5	0.013	2.6 ± 0.9	3.4 ± 1.0	0.004
Qsid, L·min−1·m−2	2.5 ± 0.6	3.3 ± 0.7	0.05	2.7 ± 0.7	2.7 ± 0.6	0.881	3.4 ± 1.0e	3.3 ± 0.7	0.842
PVR, dyn·s·cm−5	1333.7 ± 427.7	921.7 ± 384.0	<0.001	1830.8 ± 977.3	1377.5 ± 682.9	<0.001	2190.4 ± 1348.3f	1495.5 ± 759.9	0.046
SVRg, dyn·s·cm−5	1849.2 ± 520.5	1479.0 ± 404.1	0.166	1569.4 ± 381.4	1558.9 ± 373.2	0.942	1456.4 ± 811.2	1339.7 ± 621.1	0.499
PVR/SVR ratiog	0.79 ± 0.30	0.66 ± 0.24	0.089	1.48 ± 0.96	0.91 ± 0.40	0.006	2.15 ± 1.42f	1.46 ± 0.60	0.225

Abbreviations: ASD, atrial septal defects; HR, heart rates; MAP, mean systemic arterial pressure; mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PDA, patent ductus arteriosus; PVR, pulmonary vascular resistance; Qpi, pulmonary blood flow index; Qsi, systemic blood flow index; SVR, systemic vascular resistance; VSD, ventricular septal defects.

Compared with baseline values:

^aVSD group vs ASD group, P < 0.01.

^bASD group, n = 13; VSD group, n = 23; PDA group, n = 14.

^cPDA group or VSD group vs ASD group, P < 0.01.

^dASD group, n = 10; VSD group, n = 16; PDA group, n = 11.

^ePDA group vs ASD or VSD group, P < 0.05.

^fPDA group vs ASD group, P < 0.05.

^gASD group, n = 9; VSD group, n = 15; PDA group, n = 9.