Table 4.
Comparision of Changes in Clinical and Hemodynamic Parameters in Patients With Different Types of Congenital Heart Desease
| ASD | VSD | PDA | ||
|---|---|---|---|---|
| Change From Baseline | Change From Baseline | Change From Baseline | P Value | |
| 6MWD, m | 50.00 (29.00, 85.00) | 38.00 (15.50, 86.25) | 42.50 (20.50, 70.75) | 0.679 |
| Borg dyspnea index | −1.00 (−1.50, 0) | 0 (−1.00, 1.00) | 0 (−1.63, 0.75) | 0.408 |
| Improved WHO functional class | 2 (13.3) | 9 (37.5) | 5 (31.3) | 0.288 |
| SaO2, %a | 1.90 (0.05, 3.25) | 0.80 (−3.73, 4.95) | 1.40 (−0.30, 3.20) | 0.751 |
| MAP, mm Hg | −4.67 (−5.00, 3.33) | 0.83 (−6.67, 6.67) | −3.33 (−9.17, 0.00) | 0.437 |
| HR, beats/min | −6.00 (−13.00, 2.00) | 0 (−6.75, 2.75) | 0 (−7.25, 3.75) | 0.286 |
| mRAP,b mm Hg | −2.00 (−5.00, −0.34) | −1.00 (−3.00, 1.00) | −0.50 (−9.75, 4.49) | 0.627 |
| mPAP, mm Hg | −3.00 (−15.00, 2.00) | −7.00 (−15.75, −1.50) | −5.00 (−14.00, 11.42) | 0.396 |
| Qpi, L·min−1·m−2 | 0.60 (0.07, 1.95) | 0.46 (‐0.24, 0.84) | 0.63 (0.05, 1.54) | 0.527 |
| Qsic, L·min−1·m−2 | 0.62 (−0.11, 1.37) | 0.22 (−0.28, 0.41) | 0.11 (−0.62, 0.51) | 0.244 |
| PVR, dyn·s·cm−5 | −305.88 (−673.30, −238.25) | −493.03 (−755.15, −127.30) | −327.89 (−804.23, −46.99) | 0.971 |
| SVRd, dyn·s·cm−5 | −244.20 (−536.89, 166.01) | −218.71 (−467.51, 446.91) | −18.79 (−513.48, 257.78) | 0.757 |
| PVR/SVR ratiod | −0.13 (−0.30, 0.02) | −0.36 (−1.26, −0.08) | −0.56 (−0.80, 0.29) | 0.369 |
Abbreviations: 6MWD, 6‐minute walk distance; ASD, atrial septal defects; HR, heart rates; MAP, mean systemic arterial pressure; mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PDA, patent ductus arteriosus; PVR, pulmonary vascular resistance; Qpi, pulmonary blood flow index; Qsi, systemic blood flow index; SaO2, arterial oxygen saturation; SVR, systemic vascular resistance; VSD, ventricular septal defects; WHO, World Health Organization.
Changes from baseline data are expressed as median (Q1, Q3) or n (%).
ASD group, n = 13; VSD group, n = 16; and PDA group, n = 11.
ASD group, n = 13; VSD group, n = 23; PDA group, n = 14.
ASD group, n = 10; VSD group, n = 16; PDA group, n = 11.
ASD group, n = 9; VSD group, n = 15; PDA group, n = 9.