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. 2019 Jul 16;25:5280–5288. doi: 10.12659/MSM.915038

Figure 2.

Figure 2

Effect of apigenin on oxidative stress and inflammatory cytokine production in high glucose-induced HK-2 cells. HK-2 cells were incubated with 30 mM D-glucose, and (or) apigenin (100, 200 μM) for 48 h. Apigenin decreased intracellular MDA (A), and increased SOD (B) and CAT (C). ELISA was performed to determine the production of pro-inflammatory cytokines. Apigenin decreased TNFα (D), IL-1β (E), and IL-6 (F) contents in supernatant media of HK-2 cells with 30 mM D-glucose. *** P<0.001 vs. control group; ### P<0.001 vs. HG group.