Figure 1.

Petchiether A (PetA) attenuates the collagen deposition and histological injury observed in the obstructed kidneys at 5 d after unilateral obstructive (UUO) operation. Mice receiving daily intraperitoneal injection of vehicle or petA (40 mg/kg/d) 4 d before or right after UUO operation were killed 5 d after UUO. A, Haematoxylin and eosin and Masson's trichrome staining. B, Semi‐quantitative analysis of the interstitial injury score and (C) relative collagen deposition area of the obstructive kidney in each group. D, The structure of petA. Data represent the mean ± SEM for 6‐8 mice per group. *P < 0.05, ***P < 0.001 vs the sham group; ^# P < 0.05, ^## P < 0.01 vs the vehicle UUO group. Bar = 50 μmol/L. Magnification ×200. PetA Px, PetA prevention; PetA Tx, PetA treatment