Table 2.

Proposed Mechanisms of Aspirin Resistance in High‐Risk Groups

Group	Proposed Mechanisms of Resistance
Diabetes mellitus	Increased platelet turnover; decreased aspirin‐mediated acetylation
Obesity	Increased baseline platelet reactivity; increased volume of distribution; prothrombotic effects of leptin
Women	Increased COX‐1–independent signaling; increased baseline platelet reactivity
Post‐ACS	Increased platelet turnover; increased inflammation and platelet aggregation
History of stent thrombosis	Increased platelet turnover; increased peri‐procedural inflammation
Post‐CABG	Increased platelet turnover; platelet activation by bypass pump

ACS, acute coronary syndrome; CABG, coronary artery bypass graft; COX‐1, cyclooxygenase‐1.