Table 1.
Clinicopathologic characteristics of three sets of breast cancer patients according to the ER‐related signature
| Variables | Training set GPL96 (n = 357) | Validation set I GPL97 (n = 421) | Validation set II GPL570 (n = 128) | Validation set III GPL96 (n = 434) | ||||
|---|---|---|---|---|---|---|---|---|
| Low risk (%) | High risk (%) | Low risk (%) | High risk (%) | Low risk (%) | High risk (%) | Low risk (%) | High risk (%) | |
| Age at diagnosis (y) | ||||||||
| Median | 59 | 63 | 62 | 61 | 63 | 64 | ||
| ≤50 | 44 (25.7) | 37 (19.9) | 54 (21.5) | 36 (21.2) | 6 (9.4) | 3 (4.7) | ||
| >50 | 127 (74.3) | 149 (80.1) | 197 (78.5) | 134 (78.8) | 58 (90.6) | 61 (95.3) | ||
| Tumour size | ||||||||
| ≤2 cm | 135 (78.9) | 129 (69.4) | 160 (63.7) | 76 (44.7) | 35 (54.7) | 25 (39.1) | ||
| >2 cm | 36 (21.1) | 57 (30.6) | 91 (36.3) | 94 (55.3) | 29 (45.3) | 39 (60.9) | ||
| Lymph node status | ||||||||
| Negative | 131 (76.6) | 111 (59.7) | 185 (73.7) | 92 (54.1) | 26 (40.6) | 28 (43.8) | ||
| Positive | 40 (23.4) | 75 (40.3) | 66 (26.3) | 78 (45.9) | 38 (59.4) | 36 (56.3) | ||
| Grade | ||||||||
| I | 63 (36.8) | 26 (14.0) | 86 (34.3) | 35 (20.6) | 25 (39.1) | 6 (9.4) | ||
| II | 101 (59.1) | 127 (68.3) | 136 (54.2) | 94 (55.3) | 22 (34.4) | 35 (54.7) | ||
| III | 7 (4.1) | 33 (17.7) | 29 (11.6) | 41 (24.1) | 17 (26.6) | 23 (35.9) | ||
| Disease‐relapse event | 33 (19.3) | 93 (50.0) | 55 (21.9) | 92 (54.1) | 7 (10.9) | 25 (39.1) | 17 (9.6) | 74 (28.7) |
| Median follow‐up (y) | 9.5 | 5.2 | 8.9 | 4.9 | 10.5 | 7.2 | 8.7 | 6.9 |