Risk of major vascular events with or without diabetes mellitus in patients with prior ischemic events, stable atherosclerosis, and multiple risk factors only in the REACH registry. Prior ischemic events were defined as prior myocardial infarction or stroke. Error bars indicate 95% confidence intervals. Abbreviations: CV, cardiovascular; REACH, REduction of Atherothrombosis for Continued Health. Reprinted from Bhatt DL et al.5 Comparative determinants of 4‐year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis, JAMA. 2010;304:1350–1357 © (2010), with permission from the American Medical Association. All rights reserved.