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. 2019 Jul 17;13:721. doi: 10.3389/fnins.2019.00721

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Copyright © 2019 Mao, Zhou and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fer-1 enhances GPX4 protein expression and GSH level as well as decreasing MDA content and the 4-HNE level in the hippocampus of PTZ- and Pilo-treated mice. (A,B,G,H) GPX4 protein expression in the hippocampus of PTZ- and Pilo-treated mice (^∗∗∗p < 0.001, n = 4). (C,I) Detection of the GSH level in the hippocampus of PTZ- and Pilo-treated mice (^∗∗∗p < 0.001, n = 6). (D,J) Detection of the MDA content in the hippocampus of PTZ- and Pilo-treated mice (^∗∗∗p < 0.001; ^*p < 0.05, n = 6). (E,F,K,L) Detection of the 4-HNE level in the hippocampus of PTZ- and Pilo-treated mice (^∗∗∗p < 0.001, n = 6). In the Pilo-matched control group, diazepam treatment alone did not have any effect on the GPX4, GSH, MDA, and 4-HNE levels.