FIG 6.

Development of DSS-induced colitis in mice colonized with microbiota from S. mansoni-infected mice. (A) Disease activity index (DAI) score for uninfected and antibiotic-treated microbiome recipient mice cohoused with MO-infected [UI(MO)] or MF-infected [UI(MF)] mice or uninfected controls [UI(UI)] receiving DSS (filled symbols) or water (open symbols) (6 mice per group). (B) Area under the curve of DAI groups. (C) Representative H&E-stained histological sections of distal colon samples for the indicated groups (6 mice per group). (D and E) Histological score of distal colon samples and myeloperoxidase (MPO) activity for the indicated groups. Data are representative of >3 separate experiments and are presented as means ± SEM. Statistical difference between groups was determined using two-way ANOVA (A) or one-way ANOVA (B, C, and D) with Tukey’s multiple-comparison test. **, P < 0.01; ***, P < 0.001. Scale bar, 200 μm.