FIG 3.

Trained innate immune protection following multiple lethal challenges. Mice (n = 10/group) were given a primary i.p. challenge of C. dubliniensis (Cd) followed by a single C. albicans/S. aureus (Ca/Cs) lethal challenge after 14 days or by two consecutive lethal challenges separated by 20 days (for those that survived the first lethal challenge). Animals receiving no primary challenge served as the positive (lethal) control. Each group was observed for morbidity and mortality for 10 days after the final lethal challenge. Data are cumulative of two separate experiments. **, P < 0.01 (for values significantly different from those of the control, by log rank Mantel-Cox test).