Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 23;87(8):e00345-19. doi: 10.1128/IAI.00345-19

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Ysebaert et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 6 — Development of otitis media (OM) in juvenile chinchillas. (A) Adult chinchillas were immunized with adjuvanted PE, PilA, or PE-PilA or adjuvant alone. Sera were collected and used for passive transfer to juvenile chinchillas. Anti-PE and anti-PilA immune sera were combined to form the PE + PilA group. After passive transfer, the juvenile chinchillas were intranasally challenged with NTHi strain 86-028NP, and the development of otitis media was monitored by video otoscopy and tympanometry for 35 days after bacterial challenge. *, P < 0.05; **, P < 0.01; ***, P < 0.001 for PE + PilA versus AS04. (B) Adult chinchillas were immunized with adjuvanted PE-PilA or adjuvant alone. Sera were transferred to juvenile chinchillas, and the animals were intranasally challenged with NTHi strain 86-028NP. The development of otitis media was monitored in a blind manner for 35 days after bacterial challenge. **, P < 0.01 for PE-PilA versus AS04.