Table 3.
Interaction between total and subtypes of fat intake and polygenic risk score on the risk of type 2 diabetes
| Dietary factor | β interaction (SE) | P value* | Direction of interaction in included studies† | τ2‡ | Sample size |
|---|---|---|---|---|---|
| Total fat, % energy | 0.019 (0.015) | 0.20 | +−+++−++–+– | 0 | 102 350 |
| PUFA, % energy | 0.049 (0.061) | 0.43 | –++++++++−+–+ | 0.003 | 102 350 |
| MUFA, % energy | 0.040 (0.032) | 0.22 | +−+++−−++−+− | 0 | 102 350 |
| SFA, % energy | −0.017 (0.031) | 0.58 | +−+−−+−+− | 0 | 102 350 |
| omega 3 PUFA, g/d | 0.025 (0.030) | 0.40 | −?+−?−+++−+++ | 0.002 | 80 704 |
| omega 6 PUFA, g/d | 0.007 (0.005) | 0.13 | −?++?−+++−+−+ | 0 | 80 704 |
| Total trans fat, g/d | 0.009 (0.017) | 0.56 | −?−??−+−?−+++ | 0 | 68 171 |
*
For interaction.
†
For each dietary factor the combined interaction P value, heterogeneity and sample size are shown. Direction of interaction represents the sign of the β in each cohort (Cohorts presented in alphabetical order: ARIC, BHS, CHS, DCH, EPIC-InterAct, FHS, FINRISK, Health 2000, HPFS, Inter99, MDC-CC, MESA, NHS, RS-1, WGHS).
‡
Between study variance (τ2) was used to assess heterogeneity.
PUFA=polyunsaturated fat; MUFA=monounsaturated fat; SE=standard error; SFA=saturated fat; ?=not available.