Table 2.
Synergy between TPSA and anti-TB first line drugs.
| Drug combination | MIC (μg/ml) | FIC* | FIC index | |
|---|---|---|---|---|
| Alone | In combination | |||
| INH | 0.048 | 0.025 | 0.52 | 0.75 |
| TPSA | 25 | 6.34 | 0.25 | Additive |
| RFP | 0.0023 | 0.0051 | 0.22 | 0.35 |
| TPSA | 25 | 3.173 | 0.13 | Synergistic |
| EMB | 0.46 | 0.37 | 0.8 | 0.98 |
| TPSA | 25 | 4.6 | 0.18 | Additive |
*
Drug combinations were categorized based on a fractional inhibitory concentration (FIC) of ≤ 0.5 as synergistic effect, a FIC of > 0.5 and ≤ 1 as additivity, a FIC of > 1 and < 4 as drug no interaction, and a FIC of ≥ 4 as antagonistic action.