Figure 4.

Silencing of MD‐1 accelerated high‐fat diet induced myocardial dysfunction. (A‐D) Echocardiographic results for MD‐1^−/− mice and wild‐type (WT) mice after high‐fat diet feed for 20 wk (n = 12). (E) Masson's trichrome staining of heart tissues from MD‐1^−/− mice and WT mice after high‐fat diet feed for 20 wk (n = 4). (F) qPCR analysis of fibrosis markers COL1A1, COL3A1 and CTGF in MD‐1^−/− hearts and WT mice hearts after high‐fat diet feed for 20 wk (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001