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. 2019 Jul 17;7:168. doi: 10.3389/fbioe.2019.00168

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Copyright © 2019 Ahn, Lim, Jusoh, Lee, Park, Kim, Kim and Jeon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cancer cell migration in HA/fibrin composite in the microfluidic platform. (A) Schematic representation of assay to observe migration of cancer cells cultured in the HA/fibrin composite in TME co-cultured with fibroblasts. Confocal images and graphs for the number of invaded cancer cells and invasion area per ROI for (B–D) MKN74, and (E–G) SW620 respectively in HA/fibrin composite with varying HA concentration (0.0, 0.2, and 0.4%) (n = 5–9 chips per condition) (white arrows indicate nuclei of migrated tumor cell into tunable bone mimicking ECM). (Scale bar: 100 μm).