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. 2019 Jun 17;23(8):4991–5005. doi: 10.1111/jcmm.14348

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© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cell apoptosis is promoted by up‐regulated miR‐374 and silenced TYR. A, Distribution of live, apoptotic and necrotic mouse cells detected using Annexin‐V‐FITC/PI double staining; B, apoptosis rate of mouse cells in each group; C, distribution of live, apoptotic and necrotic cells of human melanoma cell line M2 detected using Annexin‐V‐FITC/PI double staining; D, apoptosis rate of human melanoma cell line M2 in each group; *P < 0.05 vs the normal group; ^# P < 0.05 vs the blank and NC groups; miR, microRNA; TYR, Tyrosinase; FITC, fluorescein isothiocyante; PI, propidium iodide; NC, negative control