Figure 1.

Serum circMTO1 levels were down‐regulated in chronic hepatitis B (CHB) patients and correlated with fibrosis markers. A, △Ct values of serum circMTO1 levels in CHB patients and healthy controls. B, Correlation between serum circMTO1 levels and the mRNA level of Col1A1. C, Correlation between serum circMTO1 levels and the mRNA level of α‐smooth muscle actin. D, △Ct values of serum circMTO1 levels in CHB patients with fibrosis score 0‐1, fibrosis score 2‐4 and fibrosis score 5‐6. E, △Ct values of serum circMTO1 levels in CHB patients with HAI score 0‐4, HAI score 5‐7 and HAI score >8. F, △Ct values of serum circMTO1 levels in CHB patients with different ALT values. △Ct method was used to calculate circMTO1 expression, which was normalized to GAPDH, and smaller ΔCt value indicated higher expression. Vertical lines indicate the range, and horizontal boundaries of the boxes represent the first and third quartiles. **P < 0.001 compared with the control