Figure 7.

Schematic representation of interplay between PSCs and PDACs mediated by BAG3 expression in PSCs. Briefly, BAG3‐positive PSCs secretes high levels of multiple cytokines/chemokines including IL‐6, IL‐8, MCP1, IGFBP2 and TGF‐β2. On one hand, IL‐8, MCP1, IGFBP2 and TGF‐β2 contribute to migration and invasion of PDACs in a paracrine manner. On the other hand, IL‐6, TGF‐β2 and IGFBP2 in turn maintain HPanSteC persistent activation in an autocrine manner. Thereby BAG3‐positive PSCs remodel tumour microenvironment favouring malignant progression of PDACs