Figure 1.

The metabolic programming of quiescent stem cells and differentiated stem cells in terms of the balance between glycolysis and oxidative phosphorylation. The common paradigm is that quiescent stem cells in the niche of normal commensal bacteria tend to prefer glycolysis accompanied with activation of anti‐oxidizing systems. On the contrary, differentiated stem cells under the niche of dysbiosis prefer oxidative phosphorylation rather than glycolysis to promote irreversible proliferation and differentiation of stem cells