Figure 2.

Control of intestinal stem cell homoeostasis through crosstalk between immune T cells and the intestinal commensal bacteria. In response to dysbiosis and increased gut permeability caused by ageing, T helper cells are activated to elicit the proliferation and differentiation of intestinal stem cells into Paneth cells and Tuft cells, accompanied with thwarting the functions of regulatory T cells which are responsible for promoting self‐renewal of intestinal stem cells. As a result, the intestinal stem cell pools are exhausted