Table 3.
Postoperative Complications for Patients with Adenocarcinoma of the Pancreas after Pancreaticoduodenectomy within 30-days of the procedure
| Neoadjuvant Therapy | Initial Surgery | p-value | |
|---|---|---|---|
| N= 926 | N= 2,822 | ||
| Postoperative death, n (%) | 16 (1.7%) | 56 (2.0%) | 0.622 |
| Overall complication, n (%) | 517 (55.8%) | 1,554 (55.1%) | 0.685 |
| 30-day Readmission, n (%) | 154 (16.6%) | 424 (15.0%) | 0.24 |
| Superficial SSI, n (%) | 89 (9.6%) | 253 (9.0%) | 0.554 |
| Deep incisional SSI, n (%) | 20 (2.2%) | 59 (2.1%) | 0.899 |
| Organ space SSI, n (%) | 76 (8.2%) | 321 (11.4%) | 0.007 |
| UTI, n (%) | 40 (4.3%) | 92 (3.3%) | 0.129 |
| Pneumonia, n (%) | 21 (2.3%) | 108 (3.8%) | 0.024 |
| Pulmonary embolism, n (%) | 6 (0.7%) | 35 (1.2%) | 0.133 |
| DVT, n (%) | 27 (2.9%) | 79 (2.8%) | 0.853 |
| Sepsis, n (%) | 74 (8.0%) | 232 (8.2%) | 0.825 |
| Septic Shock, n (%) | 26 (2.8%) | 84 (3.0%) | 0.792 |
| Acute renal insufficiency, n (%) | 2 (0.2%) | 19 (0.7%) | 0.106 |
| Acute renal failure, n (%) | 5 (0.5%) | 26 (0.9%) | 0.266 |
| Stroke, n (%) | 1 (0.1%) | 9 (0.3%) | 0.28 |
| Myocardial infarction, n (%) | 6 (0.7%) | 27 (1.0%) | 0.383 |
| Cardiac Arrest, n (%) | 8 (0.9%) | 35 (1.2%) | 0.351 |
| Wound dehiscence, n (%) | 9 (1.0%) | 34 (1.2%) | 0.564 |
| Reoperation, n (%) | 49 (5.3%) | 157 (5.5%) | 0.784 |
| Pancreatic fistula, n (%) | 85 (9.2%) | 414 (14.8%) | <0.001 |
| Grade A (ISGPF) | 55 (6.0%) | 278 (10.0%) | < 0.001 |
| Grade B (ISGPF) | 28 (3.0%) | 104 (3.7%) | 0.331 |
| Grade C (ISGPF) | 2 (0.2%) | 32 (1.2%) | 0.01 |
| Delayed gastric emptying, n (%) | 125 (13.8%) | 481 (17.6%) | 0.008 |
| Percutaneous drainage, n (%) | 91 (10.0%) | 297 (10.8%) | 0.473 |
| Perioperative transfusion, n (%) | 255 (27.5%) | 596 (21.1%) | <0.001 |
| Clavien-Dino Complication, n (%) | |||
| Grade 1 | 2 (0.2%) | 19 (0.7%) | 0.106 |
| Grade 2 | 430 (46.4%) | 1,247 (44.2%) | 0.233 |
| Grade 3 | 117 (12.6%) | 419 (14.9%) | 0.095 |
| Grade 4 | 54 (5.8%) | 192 (6.8%) | 0.3 |
| Grade 5 (death) | 16 (1.7%) | 56 (2.0%) | 0.622 |
| Complication, n (%) | |||
| Minor (Clavien-Dino 1–2) | 426 (46%) | 1,232 (43.7%) | 0.212 |
| Severe (Clavien-Dino 3–5) | 155 (16.7%) | 516 (18.3%) | 0.287 |
SSI surgical site infection; UTI urinary tract infection; DVT deep venous thrombus; ISGPF International Study Group for Pancreatic Fistula