Table 2.
Hazard ratios (HR) and 95% confidence intervals (CI) of inflammatory markers for lung cancer (Cases n=89)
| Log-Transformed | T1 | T2 | T3 | |
|---|---|---|---|---|
| CRP (ug/mL), N Cases | 718 (26) | 715 (21) | 716 (39) | |
| Baseline | ||||
| Model 1 | 1.09 (0.97, 1.22) | 1.00 | 0.86 (0.49, 1.54) | 1.85 (1.11, 3.08) |
| Model 2 | 1.03 (0.92, 1.15) | 1.00 | 0.94 (0.52, 1.69) | 1.53 (0.88, 2.65) |
| Cumulative Averaged | ||||
| Model 1 | 1.12 (0.95, 1.33) | 1.00 | 0.83 (0.48, 1.45) | 1.55 (0.96, 2.51) |
| Model 2 | 1.04 (0.88, 1.24) | 1.00 | 0.82 (0.47, 1.45) | 1.24 (0.74, 2.10) |
| Time-Updated | ||||
| Model 1 | 1.12 (0.95, 1.33) | 1.00 | 0.89 (0.52, 1.54) | 1.46 (0.89, 2.40) |
| Model 2 | 1.04 (0.88, 1.24) | 1.00 | 0.84 (0.48, 1.49) | 1.21 (0.70, 2.06) |
| IL-6 (pg/mL), Cases | 734 (17) | 735 (23) | 734 (46) | |
| Baseline | ||||
| Model 1 | 1.29 (1.04, 1.60) | 1.00 | 1.41 (0.75, 2.64) | 3.34 (1.91, 5.85) |
| Model 2 | 1.18 (0.98, 1.41) | 1.00 | 1.34 (0.70, 2.55) | 2.57 (1.41, 4.65) |
| Cumulative Averaged | ||||
| Model 1 | 1.43 (1.09, 1.89) | 1.00 | 1.15 (0.60, 2.19) | 2.47 (1.41, 4.35) |
| Model 2 | 1.18 (0.88, 1.58) | 1.00 | 0.81 (0.41, 1.61) | 1.78 (0.97, 3.24) |
| Time-Updated | ||||
| Model 1 | 1.43 (1.09, 1.89) | 1.00 | 1.28 (0.69, 2.36) | 2.47 (1.43, 4.28) |
| Model 2 | 1.18 (0.88, 1.58) | 1.00 | 0.97 (0.52, 1.83) | 1.71 (0.96, 3.05) |
| TNF-α (pg/mL), Cases | 721 (20) | 720 (32) | 720 (28) | |
| Baseline | ||||
| Model 1 | 0.96 (0.88, 1.05) | 1.00 | 1.64 (0.94, 2.89) | 1.59 (0.89, 2.85) |
| Model 2 | 0.97 (0.88, 1.06) | 1.00 | 1.76 (0.96, 3.24) | 1.82 (0.96, 3.42) |
Model 1: Adjusted for age in years, race, gender, site
Model 2: Adjusted for age in years, race, gender, site, smoking, history of pulmonary conditions, NSAID use,
body mass index, alcohol consumption, history of cardiovascular disease