Figure 7.

Transplantation of MSCs‐IL‐10, but not MSCs‐GFP improved synaptic and cell survival markers and decreased cell death markers in TBI rats. (A‐C) Pre‐synaptic and post‐synaptic markers, such as synaptophysin and PSD95 were down‐regulated by TBI and transplantation of MSCs‐IL‐10 and MSCs alone improved both, but MSCs‐IL‐10 improved greater than MSCs alone. (D) Anti‐apoptotic marker Bcl2 was increased greater by MSCs‐IL10, than MSCs alone. (E‐H) Whereas cell death markers, such as Bax, cytochrome‐C, caspase‐3 and p53 levels were increased by TBI and transplantation of MSCs‐IL10, decreased their levels more effectively than by MSCs alone. *P < 0.05 and **P < 0.01 in comparison to Sham + HBSS rats, ^# P < 0.05 and ^## P < 0.01 in comparison to TBI + MSCs