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. 2019 Jul 1;36(14):2233–2245. doi: 10.1089/neu.2018.6036

FIG. 2.

FIG. 2.

Effects of CCI and BQCA on postural and motor outcomes. Mice were evaluated at baseline and weekly thereafter after CCI or SHAM-CCI. Mice received either vehicle (SHAM-Veh; CCI-Veh) or BQCA at one of three doses (CCI-5, 5 mg/kg; CCI-10, 10 mg/kg; CCI-20, 20 mg/kg; given intraperitoneally × 2/day) across a 3-week follow-up period. Shown are group means (± SEM) for (A) body weight. (B) Postural reflex asymmetry score, (C) Grip strength as indicated by latency to fall from an inverted grid, (D) Foot slips recorded on a grid over 5 min. (E) Maximum speed achieved on the accelerating rotarod. (F) Path length in the open field over 20 min. *Indicates at each specified time point, a significant difference of SHAM-Veh compared to CCI-5, CCI-10, or CCI-20 (p < 0.05). #Indicates significant difference of CCI mice receiving BQCA relative to their vehicle counterparts. BQCA, benzyl quinolone carboxylic acid; BSL, baseline; CCI, cortex contusion injury; SEM, standard error of the mean; Veh, vehicle.