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. 2019 Jul 1;36(14):2233–2245. doi: 10.1089/neu.2018.6036

FIG. 3.

FIG. 3.

Effects of CCI and BQCA on spatial learning and memory in the Morris water maze. Mice were trained at baseline (BSL) for 7 days (6 trials/day) and then weekly (4 days/week) for 3 weeks after CCI or sham CCI. The target platform was moved to a new position at the start of each week (see top schematic). Mice received either vehicle (SHAM-Veh, CCI-Veh) or BQCA at one of three doses (CCI-5, 5 mg/kg; CCI-10, 10 mg/kg; CCI-20, 20 mg/kg; given intraperitoneally × 2/day). Top and middle graphs show, respectively, the group mean path length and latency (± SEM) traveled to find the submerged platform during each phase of the study. Baseline (BSL; brown color) includes data from all animals. *CCI- Veh versus SHAM-Veh, p < 0.05; #CCI-20 versus CCI-Veh, p < 0.05. The bottom graph shows the percent time (± SEM) spent during the probe trial at the end of week 3 searching in the quadrant (South), which previously had contained the platform. +Significant difference (p < 0.05) between the CCI-Veh group compared to SHAM-Veh, CCI-5, CCI-10, and CCI-20 groups. BQCA, benzyl quinolone carboxylic acid; CCI, cortex contusion injury; SEM, standard error of the mean; Veh, vehicle.