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. 2019 Jul 17;10:483. doi: 10.3389/fendo.2019.00483

Figure 2.

Figure 2

Intertwined oxysterol and circadian clock networks with multiple negative feedback loops and several contact points between oxysterol network and circadian clock regulation through RORA-LXR, REVERBA-INSIG, and DEC-FXR/LXR/SREBP interactions. Through contact points circadian network regulates circadian expression of oxysterol network genes and metabolites and vice versa.