Table 1.
Initial patient characteristics
| N = 48 | n | % | |
|---|---|---|---|
| Age, years | Median (range) | 55 (22–72) | |
| Gender | Male | 31 | 65% |
| Female | 17 | 35% | |
| Initial surgery | Biopsy | 15 | 31% |
| STR | 21 | 44% | |
| GTR | 12 | 25% | |
| Initial histology | Astrocytoma | 38 | 79% |
| Oligodendroglioma | 2 | 4% | |
| Oligoastrocytoma | 7 | 15% | |
| Gliosarcoma | 1 | 2% | |
| Initial grade | II | 8 | 17% |
| III | 14 | 29% | |
| IV | 26 | 54% | |
| IDH status | Mutant | 5 | 10% |
| Wild type | 23 | 48% | |
| Unknown | 20 | 42% | |
| 1p/19q status | Codeleted | 3 | 6% |
| Single deletion | 1 | 2% | |
| Intact | 4 | 8% | |
| Unknown | 40 | 83% | |
| MGMT status | Methylated | 9 | 19% |
| Unmethylated | 6 | 13% | |
| Unknown | 33 | 69% | |
| Initial chemotherapy | TMZ | 31 | 65% |
| TMZ + dasatinib | 7 | 15% | |
| TMZ + vorinostat | 3 | 6% | |
| PCV | 2 | 4% | |
| None | 5 | 10% | |
| RT dose, Gy | Median (range) | 60 (40–76) | |
| RT fractions | Median (range) | 30 (15–36) | |
| Initial GTV volume (cm3) | Median (range) | 69 (14–188) | |
| Initial PTV volume (cm3) | Median (range) | 296 (39–643) | |
STR: subtotal resection, GTR: gross total resection, IDH: isocitrate dehydrogenase, MGMT: O-6-methylguanine-DNA methyltransferase, TMZ: temozolomide, PCV: procarbazine, lomustine, vincristine, RT: radiotherapy, GTV: gross target volume, PTV: planning target volume.