Table 4.
Summary of the literature
| Citation | N | Time Period | Median time to reRT, months (range) | Median RT dose/ fx (range) | PTV volume | RN | Time to progression | Median OS after reRT, months | 1-year OS |
|---|---|---|---|---|---|---|---|---|---|
| Kim 1997 | 20 | 1988–1991 | 38 (8–234) | 36 Gy/20 fx (30.6–59.4 Gy) | GTV + 5mm | 15% | N/R | 9 | 26% |
| Shepherd 1997 | 36 | 1989–1994 | 29 (5–174) | 20–50 Gy/4–10 fx | GTV + 2mm | 34% | N/R | 11 | 45% |
| Hudes 1999 | 20 | 1994–1996 | 3.1 (0.7–45.5) | 21–35 Gy/7–10 fx | N/R | 0% | N/R | 10.5 | 20% |
| Cho 1999 | 46 | 1991–1998 | 13 (1–228) | 17 Gy to 50% (9–40 Gy) | GTV | 13% | 86% overall | 12 | 50% |
| Cho 1999 | 25 | 1991–1998 | 13 (1–228) | 37.5 Gy/15 (20–45 Gy/10–20 fx) | GTV | 4% | 86% overall | 12 | 50% |
| Selch 2000 | 21 | 1997–1999 | 11 (3–99) | 25 Gy/5 fx | N/R | 0% | Median 5 months | 6.7 | 15% |
| Voynov 2002 | 10 | 1995–2000 | 18 (2.1–251) | 30 Gy/6 fx | GTV | 20% | N/R | 10 | 50% |
| Combs 2005 | 172 | 1990–2004 | 10A (N/R) | 36 Gy/18 fx | GTV + 5-10mm | 1% | N/R | 8A | 23%A |
| Fogh 2010 | 147 | 1994–2008 | 8 (4–205) | 35 Gy/10 fx | GTV | 0% | 30% at 3 months | 11A | 50% |
| Hundsberger 2013 | 14 | 2009–2011 | 40.9 (6.1–387.9) | 41.6 Gy/16 fx (39–55 Gy) | GTV + 10–25mm | 7% | N/R | 9.1 | 35% |
| Ciammella 2013 | 15 | 2007–2012 | 10.8 (6–54) | 25 Gy/5 to 70% isodose line | GTV + 3–5mm | 13% | N/R | 9.5 | 40% |
reRT: reirradiation, RT: radiotherapy, RN: radionecrosis, PTV: planning target volume, OS: overall survival, N/R: not reported, fx: fractions.
Afor grade IV gliomas.