Table 3.
Summary of literature of extent of resection in GBM
| New/ Recurrent GBM | Survival Benefit | Study | No. Patients | Maximum Survival Advantage | Volumetric Study | Minimum Resection Required |
|---|---|---|---|---|---|---|
| New | Yes | Brown et al 201630 * | 20769 20699 |
16.1% 1-year survival 10.3% 2-year survival |
No | GTR |
| Chaichana et al 2014 (1)18 | 259 | 3.9 months | Yes | 70% or < 5 cm3 RTV | ||
| Chaichana et al 2014 (2)9 | 292 | 4.7 months (EoR) 4.2 months (RTV) | Yes | 95% or < 2 cm3 RTV | ||
| Grabowski et al14 | 128 | 4.5 months | Yes | 98% or < 2 cm3 RTV | ||
| Hollerhage et al42 | 118 | No | GTR | |||
| Keles et al 43 | 107 | 6.4 months | Yes | 75% | ||
| Kreth et al22 | 273 | 5.4 months | no | GTR | ||
| Kuhnt et al13 | 88 | 5 months | yes | 98% | ||
| Lacroix et al23 | 416 | 4.2 months | yes | 89% | ||
| Li et al10 | 1229 | 5.4 months + 5.2 months extra for addition FLAIR resection | Yes | 100% +/- 53.2% additional FLAIR resection | ||
| Local data | 285 | 4 months | No | GTR | ||
| Marko et al44 | 721 | Yes | Continuous relationship | |||
| McGirt et al17 | 451 | 2 months (GTR vs NTR); 5 months (GTR vs STR) | No | GTR | ||
| Nitta et al45 | 68 | 8 months | No | GTR | ||
| Orringer et al19 | 46 | 44% 1-year survival | yes | 90% | ||
| Roder et al11 | 117 | 13% 6-month PFS | Yes | 100% | ||
| Salvati et al20 | 105 | 3.5 months | no | GTR | ||
| Sanai et al26 | 500 | 3.8 months | Yes | 78% | ||
| Shibamoto et al46 | 135 | 4 months | No | STR | ||
| Simpson et al47 | 645 | 0.9 months (GTR vs STR); 4.7 months (GTR vs biopsy) | No | GTR | ||
| Stark et al48 | 267 | No | GTR | |||
| Stummer et al 200849 | 243 | 4.9 months | no | GTR | ||
| Stummer et al 20123 | 143 | > 7.1 months | No | Residual tumor diameter < 1.5 cm | ||
| Ushio et al50 | 105 | 5.8 months | No | GTR | ||
| Vecht et al51 | 177 | 1 month | No | Extensive surgery | ||
| No | Coburger et al16 | 33 | No difference | Yes | ||
| Kowalczuk et al52 | 52 | No difference | No | |||
| Phillips et al53 | 173 | No difference | No | |||
| Pope et al54 | 110 | No difference | Yes | |||
| Recurrent | Yes | Bloch et al55 | 107 | 3.4 months | Yes | 95% |
| McGirt et al17 | 294 | 2 months (GTR vs NTR); 6 months (GTR vs STR) |
No | GTR | ||
| Oppenlander et al56 | 170 | 10.8 months | Yes | 80% | ||
| Quick et al57 | 40 | 6.7 months | Yes | 100% | ||
| Ringel et al58 | 503 | 4.4 months | No | GTR | ||
| Suchorska et al12 | 71 | 6.4 months | Yes | 100% | ||
| Yong et al15 | 97 | 7.5 months | Yes | < 3 cm3 RTV |
EoR, extent of resection; FLAIR, fluid attenuated inversion recovery; GBM, glioblastoma; GTR, gross total resection; NTR, near total resection; PFS, progression-free survival; RTV, residual tumour volume; STR, subtotal resection. Local data = unpublished data collected locally at Addenbrookes Hospital, Cambridge, UK.
*includes a meta-analysis.