Table 5.
Results from Cox models for overall survival
| Characteristics | Hazard Ratio (95% Confidence Interval) | ||
|---|---|---|---|
| RANO Deaths / N = 81 / 95 | MacDonald Deaths / N = 81 / 95 | RECIST Deaths / N = 81 / 95 | |
| Response Criteria Outcome | |||
| Response | 0.52 (0.20–1.35) | 0.51 (0.20–1.31) | 0.48 (0.19–1.23) |
| Pseudoprogression | 0.70 (0.35–1.42) | 0.86 (0.47–1.58) | 1.00 (0.57–1.78) |
| Progression | 2.01 (1.16–3.45) | 2.27 (1.28–4.02) | 1.65 (0.89–3.06) |
| Male Sex | 0.77 (0.48–1.24) | 0.84 (0.52–1.37) | 0.81 (0.51–1.31) |
| Age (every 10 years) | 1.02 (0.80–1.31) | 1.03 (0.81–1.31) | 1.01 (0.80–1.29) |
| Baseline KPS | 1.02 (0.86–1.22) | 1.04 (0.87–1.24) | 1.03 (0.86–1.23) |
| Disease Extent | |||
| Non-measurable | 0.60 (0.29–1.24) | 0.58 (0.27–1.22) | 0.67 (0.27–1.22) |
| Measurable | 0.85 (0.43–1.66) | 0.81 (0.41–1.61) | 0.76 (0.38–1.53) |
RANO, Response Assessment in Neuro-Oncology; RECIST, Response Evaluation Criteria in Solid Tumours