Table 3.
Results from Cox proportional hazards models estimating the association between antidepressant medication (ADM) adherence and opioid cessation among patients with chronic opioid use ((>90 days) with a new depression episode (NDE, 2002–2012) (n = 2821).
| Hazard ratio (95% CI) | |||
|---|---|---|---|
|
|
|||
| Variable | Model 1 - Crudea | Model 2 – Weightedb | Model 3 – Weighted + Painc |
| ADM adherence ≥80% | 1.05 (0.88–1.24) | 1.24 (1.05–1.46) | 1.24 (1.05–1.46) |
| Arthritis | 0.97 (0.73–1.30) | ||
| Back pain | 0.77 (0.59–1.01) | ||
| Headache | 1.13 (0.95–1.33) | ||
| Musculoskeletal pain | 1.09 (0.88–1.34) | ||
| Neuropathy | 0.96 (0.81–1.13) | ||
| Pain score | 1.02 (0.99–1.05) | ||
Results in bold are significant.
a
Unweighted data.
b
Inverse probability of adherence weighted data to control for confounding factors shown in Table 1.
c
Additional adjustment for painful conditions and pain scores after date of ADM initiation.