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. Author manuscript; available in PMC: 2019 Jul 24.
Published in final edited form as: Cell Rep. 2019 Jul 9;28(2):368–381.e6. doi: 10.1016/j.celrep.2019.06.025

Figure 4. Peri- to Post-Menopausal Transition Results in Decline of Muscle Satellite Cells in Humans.

Figure 4.

(A) Subject characteristics of women participants (n = 5).

(B) Representative images of DAPI stained nuclei (blue), Pax7 satellite cells (gold), and merged images from cross sections of muscle biopsies from perimenopausal women and of the same women when post-menopausal status was reached. Scale bars, 50 μm.

(C) Quantification of percentage of Pax7+ cells counted in each cross section relative to the total number of fibers in muscle biopsies from peri-menopausal and post-menopausal women (p = 0.057).

(D) Declines in the percentage of Pax7+ cells in muscle cross sections of four out of five individual women during the two menopausal stages.

(E) Individual serum estradiol (E2) levels in women during the two menopausal stages.

(F) Pearson correlation between E2 and %Pax7+ cells (p = 0.023). Peri-menopausal women shown in closed circles and post-menopausal women shown in open circles (def).