Table 2. CRC-like organoids with the acquired mutations related to the stage.
| Organoid mutation | CRC-like stage |
|---|---|
| - | WT |
| APCfl/fl | I |
| APCfl/fl, KRASG12D/WT | II |
| APCfl/fl, KRASG12D/WT, P53fl/R172H | III |
| APCfl/fl, KRASG12D/WT, P53fl/R172H, Smad4fl/fl | IV |
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