Table 2. Average number of SMN copies per population.
Asterisks (*) indicate a significant difference in prevalence.
| SMN1 copy number | Europe n = 396 Count (%) |
Asia n = 304 Count (%) |
Africa n = 346 Count (%) |
Americas n = 209 Count (%) |
||||
|---|---|---|---|---|---|---|---|---|
| 1 | 11 (2.8) | 2 (0.7) | 1 (0.3) | 4 (1.9) | ||||
| 2 | 364 (91.9) | 279 (91.8) | 152 (43.9) | 177 (84.7) | ||||
| 3 | 21 (5.3) | 22 (7.2) | 143 (41.3) | 27 (12.9) | ||||
| 4 | 0 | 1 (0.3) | 50 (14.5) | 1 (0.5) | ||||
| Average | 2.03 | 2.07 | 2.70 | 2.12 | ||||
| SMN2 copy number | ||||||||
| 0 | 27 (6.8) | 12 (3.9) | 80 (23.1) | 15 (7.2) | ||||
| 1 | 158 (39.9) | 117 (38.4) | 174 (50.3) | 82 (39.2) | ||||
| 2 | 195 (49.2) | 168 (55.3) | 86 (24.9) | 107 (51.2) | ||||
| 3 | 15 (3.8) | 7 (2.3) | 6 (1.7) | 5 (2.4) | ||||
| 4 | 1 (0.3) | 0 | 0 | 0 | ||||
| Average | 1.51 | 1.56 | 1.05 | 1.49 | ||||
| SMN1/2Δ7–8 copy number | ||||||||
| 1 | 58 (14.6) | 1 (0.3) | 1 (0.3) | 18 (8.6) | ||||
| 2 | 4 (1.0) | 0 | 0 | 0 | ||||
| Average | 0.17* | 0.003* | 0.003* | 0.09 | ||||
| Average copy number of SMN1,SMN2 and SMN1/2Δ7–8 | 3.70 | 3.64 | 3.75 | 3.69 | ||||
| Average copy number of SMN1 and SMN2 | 3.54 | 3.63 | 3.75 | 3.61 | ||||
* p < 0.001