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. 2018 Jun 14;6(2):144–155. doi: 10.1093/nop/npy019

Table 1.

Studies Included for Analysis. *= Prospective Studies **=Randomized Trial

Author Year Type Sample size (n) Total / Grade IV Age (years) Initial XRT (Gy) Re-irradiation (Gy) Cumulative (Total) EQD2 (Gy) Median interval (months) Median PTV (ml) Median Overall Survival (months) Radionecrosis (%)
Total dose Dose per fraction EQD2 Total dose Dose per fraction EQD2
Arcicasa 1 * 1999 Conventional 24 NR 44 60 2 60 34.5 1.5 30.2 90.2 14 NR 8.5 0
Neider 1 * 1999 Conventional 32 21 44 58.5 1.3 48.3 45.5 1.3 37.5 85.8 20 NR 6.6 6.25
Verninga 1 2001 Conventional 22 17 34 60 2 60 46 2 46 106 32.8 NR 11.3 4.54
Combs 17 2005 Conventional 40 0 42 59.4 2 59.4 36 2 36 95.4 34.5 56.2 16 0
Combs 1 2005 Conventional 101 59 50 60 2 60 36 2 36 96 19.14 49.3 11.32 1
Combs 1 2005 Conventional 53 51 55 57 2 57 36 2 36 93 10 49 8 0
Adkison 19 * 2011 Conventional 76 0 45.5 59.4 2 59.4 50 2 50 109.4 18.2 369.2 10.4 0
Maier-Hauff 1 * 2011 Conventional 59 59 55.7 NR NR - 30 2 30 - NR 46.5 13.4 0
Niyazi 17 2012 Conventional 30 22 51.5 60 2 60 36 2 36 96 NR NR NR 0
Niyazi 20 2012 Conventional 39 30 51 60 2 60 36 2 36 96 21.4 NR 7.7 NR
Sholtyssek 21 2013 Conventional 64 11 53.4 60 2 60 36 2 36 96 13.4 110.4 NR 0
Niyazi 22 2013 Conventional 58 46 52 60 2 60 36 2 36 96 21.4 NR 11.4 0
Osman 23 2014 Conventional 29 20 42.1 60 2 60 36 2 36 96 13 NR 7.8 0
Fleiger 24 * 2014 Conventional 71 52 53 60 2 60 36 2 36 96 NR NR 10.8 0
Niyazi 25 2014 Conventional 31 25 51 60 2 60 36 2 36 96 34 118.1 11.5 NR
Wick 26 ** 2014 Conventional 91 91 57.6 NR NR - 36 2 36 - NR NR 6.9 NR
Magnussen 27 2014 Conventional 23 23 53 60 2 60 54 2 54 114 11.8 424 14.7 0
Aktan 28 2015 Conventional 21 18 48 60 2 60 54 2 54 114 39.4 NR 9 0
Schnell 29 2016 Conventional 105 85 48.5 60 2 60 36 2 36 96 17.7 105.8 10.3 0
Jeongshim 30 2016 Conventional 29 21 42.5 59.4 2 59.4 45 1.8 42.8 102.2 30.5 NR 13.7 10.34
Alexander 1 1992 SRS 25 16 45 59.4 2 59.4 13 13 48.8 108.2 14 10 9 12
Hall 17 1995 SRS 35 26 47 60 1.8 57 20 20 110 167 8 28 6.5 14
Shreive 1 1995 SRS 86 86 46 NR NR - 13 13 48.8 - 10.3 10.1 10.2 22
Larson 1 1996 SRS 93 66 49.9 NR NR - 16 16 72 - NR 6.7 13 NR
Kondziolka 1 1997 SRS 42 19 47.8 60 2 60 15.2 15.2 65.4 125.4 14.3 6 30 7.1
Van Kampen 17 * 1998 SRS 27 27 NR 60 2 60 16 16 72 132 9.6 21 9 0
Cho 1 1999 SRS 46 27 48 60 1.8 57 17 17 80.8 137.8 10 30 11 4.3
Park 1 2000 SRS 23 23 53 NR NR - 15 15 63.8 - NR 9.9 10.3 NR
Larson 1 * 2002 SRS 26 14 48.8 NR NR - 15 15 63.8 - NR 12.3 12.95 NR
Combs 1 2005 SRS 32 32 56 54 2 54 15 15 63.8 117.8 10 10 10 0
Hseih 1 2005 SRS 26 26 58 60 2 60 12 12 42 102 NR 21.6 10 31.3
Mahajan 1 * 2005 SRS 41 41 54 60 2 60 NR NR - - 10 4.7 11 NR
Kong 1 * 2008 SRS 114 65 49 60 2 60 16 16 72 132 NR 10.6 16.25 24.4
Patel 1 2009 SRS 26 26 53 60 2 60 18 18 90 150 12.5 10.4 8.4 NR
Villavicencio 17 2009 SRS 26 26 56.4 60 2 60 20 10 60 120 10 7 7 NR
Pouratian 17 2009 SRS 26 26 60.1 60 2 60 17 17 80.8 140.8 NR 21.3 9.4 0
Cuneo 31 2012 SRS 63 49 47 60 2 60 15 15 63.8 123.8 NR 4.8 10 10
Skeie 32 2012 SRS 51 51 51 60 2 60 12.2 12.2 43.3 103.3 11 12.4 12 0
Park 33 2012 SRS 44 44 64 60 2 60 15 15 63.8 123.8 16.8 9.5 12.2 0
Elliott 34 2012 SRS 26 16 60.4 60 2 60 15 15 63.8 123.8 5.8 1.2 13.5 8
Conti 35 * 2012 SRS 23 23 58 60 2 60 20 10 60 120 7 13.8 12 4.3
Martinez Carillo 36 2014 SRS 51 26 48 60 2 60 18 18 90 150 13.8 6 10 10
Pinzi (sSRS)37 2015 SRS 42 NR 51 58 2 58 15 15 63.8 121.8 11 2 11.5 6
Pinzi (mSRS)37 2015 FSRT 86 NR 51 58 2 58 23 7.66 55.5 113.5 11 11 11.5 6
Glass 1* 1997 FSRT 20 13 44 NR NR - 42 NR - - 8 NR 13.7 15
Shepherd 1 1997 FSRT 33 0 37 55 1.8 52.25 35 5 61.25 113.5 29 NR 10.7 12
Cho 17 1999 FSRT 25 15 53 60 1.8 57 37.5 2.5 42.1875 99.1875 19 NR 12 5
Hudes 1* 1999 FSRT 20 19 52 60 1.8 57 24–35 3–3.5 48.2 max 105.2 max 3.1 NR 10.5 0
Selch 1 2000 FSRT 21 14 54 60 2 60 25 5.00 43.75 103.75 11 NR 6.7 0
Lederman 1* 2000 FSRT 88 88 56 60 1.8 57 24 6 48 105 7.8 NR 7 8
Grosu 1* 2005 FSRT 44 35 50 60 1.8–3 57–75 30 5 52.5 109.5–127.5 16 NR 8 0
Wurm 1* 2006 FSRT 25 20 45 60 1.8 57 25–30 5 43.75–52.5 100.75–109.5 12.8 NR 14.5 0
Kohshi 1* 2007 FSRT 25 11 46 60 2 60 22 2.8 26.1 86.1 11 NR 15.5 28
Fokas 1* 2009 FSRT 53 53 53 54 2 54 30 3 37.5 91.5 NR 35.01 9 0
Gutin 1* 2009 FSRT 25 20 56 59.4 1.8 56.4 30 6 60 116.4 14.5 34 12.5 0
Henke 38 2009 FSRT 31 29 50 59 2 59 20 5 35 94 18 NR 5.3 0
Fogh 1 2010 FSRT 147 105 53 60 2 60 35 3.5 48.1 108.1 8 NR 11 0
Minniti 39* 2011 FSRT 36 36 56 60 2 60 37.5 2.5 42.2 102.2 14 32.1 9.7 8
Mckenzie 39* 2013 FSRT 35 29 62 59.4 1.8 56.4 30 6 60 116.4 NR 8.54 8.6 9
Shapiro 40 2013 FSRT 24 20 56 59.4 1.8 56.4 30 6 60 116.4 12.6 35 12.2 0
Minniti 47 2015 FSRT 54 42 54 60 2 60 25 5 43.8 103.8 14 33.1 9.6 5
Ertas 41 2014 FSRT 42 30 52 60 2 60 18 6 36 96 19 42 8.85 4.7
Miwa 42* 2014 FSRT 21 21 53.9 60 2 60 30 6 60 120 12 27.4 11 9.5
Yacizi 43* 2014 FSRT 37 37 NR 60 2 60 30 6 60 120 NR NR 10.6 2.7
Palmer 44 2015 FSRT 231 208 54.125 60 2 60 35 3.5 48.1 108.1 10.2 NR 10.77 0
Antoni 45 2015 FSRT 20 12 55.7 60 2 60 31.2 6.25 64.4 124.4 18.3 2.71 15.6 NR
Scorsetti 46 2015 FSRT 21 21 50 60 2 60 25 5 43.8 103.8 13 NR 11 0
Dincoglan 48 2015 FSRT 28 28 55.6 60 2 60 25 5 43.8 103.8 11.2 36.5 10.3 11
Zwirner 49 2016 FSRT 36 NR 55.9 60 2 60 NR NR - - NR 55.1 10.7 0
Navarria 50 2016 FSRT 25 13 50 60 2 60 25 5 43.8 103.8 NR 35 18 0
Pinzi (mSRS)37 2015 FSRT 86 NR 51 58 2 58 23 7.66 55.5 113.5 11 11 11.5 6
Glass 1* 1997 FSRT 20 13 44 NR NR - 42 NR - - 8 NR 13.7 15
Shepherd 1 1997 FSRT 33 0 37 55 1.8 52.25 35 5 61.25 113.5 29 NR 10.7 12
Cho 17 1999 FSRT 25 15 53 60 1.8 57 37.5 2.5 42.1875 99.1875 19 NR 12 5
Hudes 1 * 1999 FSRT 20 19 52 60 1.8 57 24–35 3–3.5 48.2 max 105.2 max 3.1 NR 10.5 0
Selch 1 2000 FSRT 21 14 54 60 2 60 25 5.00 43.75 103.75 11 NR 6.7 0
Lederman 1 * 2000 FSRT 88 88 56 60 1.8 57 24 6 48 105 7.8 NR 7 8
Grosu 1 * 2005 FSRT 44 35 50 60 1.8–3 57–75 30 5 52.5 109.5–127.5 16 NR 8 0
Wurm 1 * 2006 FSRT 25 20 45 60 1.8 57 25–30 5 43.75–52.5 100.75–109.5 12.8 NR 14.5 0
Kohshi 1 * 2007 FSRT 25 11 46 60 2 60 22 2.8 26.1 86.1 11 NR 15.5 28
Fokas 1 * 2009 FSRT 53 53 53 54 2 54 30 3 37.5 91.5 NR 35.01 9 0
Gutin 1 * 2009 FSRT 25 20 56 59.4 1.8 56.4 30 6 60 116.4 14.5 34 12.5 0
Henke 38 2009 FSRT 31 29 50 59 2 59 20 5 35 94 18 NR 5.3 0
Fogh 1 2010 FSRT 147 105 53 60 2 60 35 3.5 48.1 108.1 8 NR 11 0
Minniti 39 * 2011 FSRT 36 36 56 60 2 60 37.5 2.5 42.2 102.2 14 32.1 9.7 8
Mckenzie 39 * 2013 FSRT 35 29 62 59.4 1.8 56.4 30 6 60 116.4 NR 8.54 8.6 9
Shapiro 40 2013 FSRT 24 20 56 59.4 1.8 56.4 30 6 60 116.4 12.6 35 12.2 0
Minniti 47 2015 FSRT 54 42 54 60 2 60 25 5 43.8 103.8 14 33.1 9.6 5
Ertas 41 2014 FSRT 42 30 52 60 2 60 18 6 36 96 19 42 8.85 4.7
Miwa 42 * 2014 FSRT 21 21 53.9 60 2 60 30 6 60 120 12 27.4 11 9.5
Yacizi 43 * 2014 FSRT 37 37 NR 60 2 60 30 6 60 120 NR NR 10.6 2.7
Palmer 44 2015 FSRT 231 208 54.125 60 2 60 35 3.5 48.1 108.1 10.2 NR 10.77 0
Antoni 45 2015 FSRT 20 12 55.7 60 2 60 31.2 6.25 64.4 124.4 18.3 2.71 15.6 NR
Scorsetti 46 2015 FSRT 21 21 50 60 2 60 25 5 43.8 103.8 13 NR 11 0
Dincoglan 48 2015 FSRT 28 28 55.6 60 2 60 25 5 43.8 103.8 11.2 36.5 10.3 11
Zwirner 49 2016 FSRT 36 NR 55.9 60 2 60 NR NR - - NR 55.1 10.7 0
Navarria 50 2016 FSRT 25 13 50 60 2 60 25 5 43.8 103.8 NR 35 18 0
Miwa 42 * 2014 FSRT 21 21 53.9 60 2 60 30 6 60 120 12 27.4 11 9.5
Yacizi 43 * 2014 FSRT 37 37 NR 60 2 60 30 6 60 120 NR NR 10.6 2.7
Palmer 44 2015 FSRT 231 208 54.125 60 2 60 35 3.5 48.1 108.1 10.2 NR 10.77 0
Antoni 45 2015 FSRT 20 12 55.7 60 2 60 31.2 6.25 64.4 124.4 18.3 2.71 15.6 NR
Scorsetti 46 2015 FSRT 21 21 50 60 2 60 25 5 43.8 103.8 13 NR 11 0
Dincoglan 48 2015 FSRT 28 28 55.6 60 2 60 25 5 43.8 103.8 11.2 36.5 10.3 11
Zwirner 49 2016 FSRT 36 NR 55.9 60 2 60 NR NR - - NR 55.1 10.7 0
Navarria 50 2016 FSRT 25 13 50 60 2 60 25 5 43.8 103.8 NR 35 18 0

Abbreviations: XRT, radiotherapy; EQD2, equivalent dose in 2Gy per fraction; PTV, planning target volume; SRS, stereotactic radiosurgery; FSRT, fractionated stereotactic radiotherapy.