Table 5.
Multivariate Analysis
| Median age | Median interval (months) | Total EQD2 (Gy) | Re-irradiation EQD2 (Gy) | Dose per fraction (Gy) | PTV (ml) | Type | |
|---|---|---|---|---|---|---|---|
| Model 1 (MOS) | 0.08-month decreased survival [95% CI, 0.03–0.13 months less] P = .0019 |
0.25-month increased survival [95% CI, 0.02–0.3 months greater] P < .0001 |
0.03-month increased survival [95% CI, 0.01–0.04 months greater] P = .0004 |
- | - | 0.014-month decreased survival [95% CI, 0.01–0.02 months less] P < .0001 |
*Conventional as reference SRS 3.8 month increased survival [95%CI, 3.0–4.6 months greater] FSRT 1.5 month increased survival [95%CI, 0.9–2.2 months greater] P < .0001 |
| Model 2 (MOS) | 0.02-month decreased survival [95% CI, 0.02–0.07 months less] P = .30 [Non-confounder] |
0.28-month increased survival [95% CI, 0.24–0.32 months greater] P < .0001 |
- | 0.014-month decreased survival [95% CI, 0.0003 months greater–0.03 less] P = .055 [Confounder] |
- | 0.014-month decreased survival [95% CI, 0.01– 0.02 months less] P < .0001 |
*Conventional as reference SRS 3.2 months increased survival [95%CI, 2.5–4.0 months greater] FSRT 1.2 months increased survival [95%CI 0.5–1.8 months greater] P < .0001 |
| Model 3 (MOS) | 0.02-month decreased survival [95% CI, 0.07 months less–0.02 greater] P = .28 [Non-confounder] |
0.28-month increased survival [95% CI, 0.24–0.32 months greater] P < .0001 |
- | - | 0.04-month decreased survival [95% CI, 0.1 months less– 0.03 greater P = .34 [Confounder] |
0.014-month decreased survival [95% CI, 0.01–0.02 months less] P < .0001 |
*Conventional as reference SRS 3.2 months increased survival [95%CI, 2.1–4.3 months greater] FSRT 1.1 months increased survival [95%CI, 0.5–1.8 months greater] P < .0001 |
| Model 4 (RN) | 0.37% decreased rate [95% CI, 0.3–0.41 less] P < .0001 |
0.23% decreased rate [95% CI, 0.19–0.27 less] P < .0001 |
0.10% increased rate [95% CI, 0.09–0.11 greater] P < .0001 |
- | - | 0.01% decreased rate [95%CI 0.009–0.013 less] P < .0001 |
*Conventional as reference SRS 0.4% increased rate [95%CI, 0.2–1.0% greater] FSRT 4% increased rate [95%CI, 3.4 to 4.4 greater] P < .0001 |
| Model 5 (RN) | 0.78% decreased rate [95% CI, 0.73–0.84 less] P < .0001 |
0.48% decreased rate [95% CI, 0.42–0.55 less] P < .0001 |
- | 0.03% increased rate [0.01– 0.05% greater] P ≤.0005 |
- | 0.01% decreased rate [95%CI 0.007–0.014 less] P < .0001 |
*Conventional as reference SRS 5.0% increased rate [95%CI, 4.1–5.9 greater] FSRT 6.0% increased rate [95% CI, 5.3–6.8 greater] P < .0001 |
| Model 6 (RN) | 0.78% decreased rate [95% CI, 0.72–0.84 less] P < .0001 |
0.48% decreased rate [95% CI, 0.42–0.54 less] P < .0001 |
- | - | 0.03% decreased rate [95% CI, 0.13% less-0.06% greater] P = .43 [Confounder] |
0.01% decreased rate [95% CI, 0.009–0.015 less] P < .0001 |
*Conventional as reference SRS 4.5% increased rate [95%CI, 3.2–5.9% greater] FSRT 5.8% increased rate [95%CI, 5.0–6.6% greater] P < .0001 |